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Randomized Controlled Trial of Tinospora crispa

543

Chawanya Sangsuwan MD*, Suthipol Udompanthurak MSc**,
Sathit Vannasaeng MD*, Visanu Thamlikitkul MD*
* Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
** Department of Research Promotion, Faculty of Medicine Siriraj Hospital, Mahidol University

Abstract


A randomized double blind placebo controlled trial was conducted to determine the efficacy of
Tinospora crispa as additional treatment in patients with type 2 diabetes mellitus who did not respond to
oral hypoglycemic drugs and refused insulin injection. Twenty patients were allocated to receive Tinospora
crispa powder in capsule form at a dosage of 1 gram thrice daily for 6 months. Twenty patients received a
placebo. The main outcomes were changes in fasting plasma glucose, glycosylated hemoglobin and insulin
levels. The baseline characteristics of the patients in both groups were not significantly different. There were
no significant changes in fasting plasma glucose, glycosylated hemoglobin and insulin levels among the
patients within the group and between groups. Two patients who received Tinospora crispa showed marked
elevation of liver enzymes that returned to normal after discontinuing Tinospora crispa. Moreover, patients
in the Tinospora crispa group had significant weight reduction and cholesterol elevation while taking
Tinospora crispa. It is concluded that there is no evidence to support the use of Tinospora crispa 3 grams a
day for additional therapy in patients with type 2 diabetes mellitus who did not respond to oral hypoglycemic
drugs. The patients receiving Tinospora crispa may have an increased risk of hepatic dysfunction.

Keyword : Tinospora crispa, Diabetes mellitus



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