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Electron Microscopic Study in a Case of


Piti Palungwachira MD, PhD*,
Hitoshi Yaguchi MD, PhD**, Pranee Palungwachira MD***
* Srinakharinwirot University Skin Center
** Department of Dermatology, Juntendo University, Hongo, Bunkyo-ku, Tokyo
*** Department of Family Medicine, Faculty of Medicine, Ramathibodi Hospital


The authors report a solitary mastocytoma with a solitary red infiltrated plaque on the dorsum of
the right foot for 2 months. Histologically there were numerous mast cells infiltrating the dermis. Electron
microscopy revealed CLCs located in phagosomes of activated macrophages as well as in the stromal tissue,
close association between CLCs formation and damaged eosinophils was documented. Charcot-Leyden
crystals (CLCs) have been found in many conditions associated with eosinophilia, but their occurrence in
skin diseases is very rare. These occurrences showed the evidence that the formation of CLCs in a mastocytoma
correlated to the individual and related to the biology of mast cells, basophils, eosinophils and macrophages.
Phagosomes probably acted as the localization of CLCs formation. The pathological role of CLCs in a
mastocytoma needs further investigation.

Keyword : Mastocytoma , Electron microscopy

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