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Prevalence of Lipodystrophy in Thai-HIV Infected Patients

605

Suchittra Puttawong MSc In Pharm*,
Wisit Prasithsirikul MD*, Somratai Vadcharavivad Pharm D**
􀃊 Oral presentation at the Annual Conference 2002, Infectious Disease Association of Thailand, October
10-13, 2002, Surat Thani, and The 19th Annual Meeting of the Royal College of Physicians of Thailand,
April 19-23 2003, Ambassador City Hotel, Jomtien, Pattaya, Thailand
* Bamrasnaradura Infectious Disease Institute
** Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University

Abstract


To determine the prevalence and clinical characteristics of lipodystrophy in HIV-infected Thai
patients, a cross-sectional study was performed on 278 HIV-infected patients at Bamrasnaradura Infectious
Disease Institute. Laboratory data related to lipid and glucose metabolism were obtained from both patients
who self reported fat maldistribution or diagnosed by a physician. The history of antiretroviral treatment
and HIV infection were recorded. Prevalence of lipodystrophy found in the present study was 17%.
Lipodystrophy was reported mostly on the face, buttock, legs, arms, and abdomen respectively. Two-thirds of
these patients had mixed syndromes of fat accumulation and fat wasting and the others had only fat wasting.
Ninety-three percent of lipodystrophic patients had at least 1 abnormality in either lipid or glucose metabolism.
Eighty-eight percent had dyslipidemia, 21% had impaired glucose tolerance, 30% had insulin resistance
and 27% had diabetes mellitus. Lipodystrophic patients have a high rate of lipid and glucose metabolism
abnormalities which are the major risk factors for cardiovascular events.

Keyword : Lipodystrophy syndromes, HIV infection, Antiretroviral drug, Adverse drug reaction, Prevalence



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