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Bronchiolitis Obliterans Syndrome After Heart-Lung Transplantation: A Case Report and Review of Literature


Chanchai Sittpunt *,
Somkiat Wongtim *, Visith Udompanich *,
Kamol Kaewkittinarong *, Kittichai Luengtaviboon **
* Department of Medicine, Faculty of Medicine, Chulalongkorn University
** Department of Surgery, Faculty of Medicine, Chulalongkorn University


Bronchiolitis obliterans syndrome (BOS) is regarded as a manifestation of chronic rejection after
lung transplantation and remains the major cause of late morbidity and mortality after lung and heart-lung
transplantation. The authors, herein, reported the first documented case of a patient who receiving heartlung
transplantation at our institute and developed BOS as a late complication. The patient presented 5
years after received heart-lung transplantation with progressive shortness of breath due to obstructive lung
disease. He was diagnosed with BOS by typical clinical presentation, pulmonary function test and radiographic
findings and there were no other identified etiologies of airway obstruction. The authors also reviewed the
recent update on the diagnosis and management of BO after lung transplantation.

Keyword : Bronchiolitis obliterans syndrome

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