Proundly Supported by
Pfizer Foundation
    Home | Current Issue | Past Issue | Board | Instruction | Contact


Safety and Efficacy of a Simplified Fixed-Dose Combination of Stavudine, Lamivudine and Nevirapine (GPO-VIR®) for the Treatment of Advanced HIV-Infected Patients: A 24-Week Study

760

Thanomsak Anekthananon MD*,
Winai Ratanasuwan MD*, Wichai Techasathit MD*,
Areeaue Sonjai BS*, Surapol Suwanagool MD*
* Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University

Abstract


Objective : To determine the efficacy and safety of the fixed-dose combination of stavudine (d4T), lamivudine (3TC) and nevirapine (NVP) in the treatment of antiretroviral naïve HIV-infected Thai adults.
Patients And Method : An open-label, single arm trial was conducted. Baseline clinical assessment and blood test was done on 101 antiretroviral naïve HIV-infected patients, who then received a fixed dose combination of d4T, 3TC and NVP (GPO-VIR®, Thai Government Pharmaceutical Organization, Bangkok, Thailand). Nevirapine was given as 200 mg once daily for the first 2 weeks. The patients were followed up at 2, 4, 8, 12 and 24 weeks. A CD4 cell count and HIV-RNA assay were done at 12 and 24 weeks.
Results : One hundred and one patients were enrolled. The mean baseline CD4 cell count and mean HIV RNA were 58.7 (57.7) cells/mm3 and 5.3 (0.5) log10 copies/mL respectively. At week 24th, the mean decrease in log HIV RNA was 3.6 (0.7) log10 copies/mL [P < 0.001; 95% confidence interval (CI), 2.70-3.03]. Eighty one (80.2%) patients had HIV RNA < 400 copies/mL by intention-to-treat analysis (ITT) and 97.6% had HIV RNA < 400 copies/mL by on-treatment analysis (OT). Sixteen (84.2%) patients with baseline HIV RNA < 100,000 copies/mL and 65 (82.3%) patients with baseline HIV RNA > 100,000 copies/mL had viral load < 400 copies/mL by ITT (P = 0.842; 95% CI, -20.9%-16.2%). Sixteen (94.1%) patients with baseline HIV RNA < 100,000 copies/mL and 65 (98.5%) patients with baseline HIV RNA > 100,000 copies/mL had viral load < 400 copies/mL by OT (P = 0.295; 95% CI, -25.5%-3.8%). The mean CD4 cell count at week 24 was 155.1 (89.0) cells/mm3 (range 13-402). The mean increase in CD4 cell count from baseline was 96.5 (63.5) cells/mm3 (P < 0.001). A total of 12% of the patients receiving d4T + 3TC + NVP developed skin rashes. Grade 3 or 4 hepatotoxicity was recognized in 7% of the patients.
Conclusion : Fixed-dose combination of d4T + 3TC + NVP (GPO-VIR®) is safe, well tolerated and effective in increasing CD4 cell counts and suppression of HIV RNA at 24 weeks in advanced HIV-infected patients in Thailand.

Keyword : Safety, Efficacy, Antiretroviral treatment, AIDS



Download Full Paper
  Vol87_No7_760.pdf  [ 106.47 Kb]

Home | Current Issue | Past Issue | Board | Instruction | Contact

© Copyright The Medical Association of Thailand. All Rights Reserved.2001-2002
Acquista Cialis generico 5 mg Effetti collaterali del Cialis 5 mg Acquista Cialis 20mg online Prezzo di Cialis originale in Svizzera Acquista Viagra in Svizzera senza prescrizione Dove comprare Cialis 10mg Viagra in farmacia online effetti collaterali Costo di Cialis 5mg Opiniones de Reduslim Acquista Spedra Avanafil senza prescrizione Acquista Viagra in Svizzera senza prescrizione Comprar Cialis original Comprar Viagra Contrareembolso Cialis 5mg Viagra sin receta Cialis 5 mg efectos secundarios graves Reduslim precio Trastorno de la ereccin venta de tadalafilo avanafil prezzo cialis 20 mg prezzo cialis effetti benefici cialis 10 mg Reduslim Kaufen pulse crypto price prediction avanafil 100 mg prezzo buy cialis or generic tadalafil 9 http://diplomsagroups.com https://gosznac-diploma.com/ http://sreestrom.ru/ http://originality-diplomy.com https://russian-diplom.com 9 http://russdiplomiki.com https://diplomansy.com 11 https://diploms-asx.com http://diplomrussian.com 11 https://rudiplomisty24.com/ https://russiany-diploman.com/ https://land-diplom.com/ 11 https://kyc-diplom.com http://diploms-service.com https://originaly-dokuments.com https://diplomy-grup24.com/ http://aurus-diploms.com/kupit-diplom-stroitelya.html 9 https://diplomansy.com/kupit-diplom-s-reestrom http://diploms-service.com/diplomy-po-gorodam/novosibirsk 11 http://diplomyland.com/ https://premialnie-diplomansy.com https://diplomiki.com
https://aurus-diplomany.com
https://russiany-diplomana.com
https://originality-diplomik.com
https://lands-diplomy.com
https://okdiplom.com/
https://nsk-diplom.com/
https://ry-diplom.com/
https://diploms-vuza.com/
https://diplom-bez-problem.com/
https://kazdiplomas.com/
https://diplomoz-197.com/
https://kupit-diplomyz24.com/
https://prodiplome.com/
https://diplom5.com/
https://10000diplomov.ru/
https://1magistr.ru/
https://diplom-insti.ru/
https://kdiplom.ru/
https://diplom45.ru/
https://diplom-zakaz.ru/
https://peoplediplom.ru/
https://diplom-profi.ru/
https://bisness-diplom.ru/
https://kupite-diplom0024.ru/
11
11
11
https://diploman-asx.com
11
https://rudiplomirovany.com
https://premialnie-diploms.com
https://diplomans-doc.com
https://russiany-diplom.com
https://diplomy-gruppa.com
https://rudiplomis.com
https://rudiplomisty.com/
https://lands-diploms.com
https://originality-diploman.com
https://originality-diplomx24.com
https://originality-diploms24.com
https://originality-diploma24.com
https://originality-diploman24.com
https://originality-diplomans24.com
https://originality-diplomik24.com
https://originality-diplomix24.com
https://originality-diplomas24.com
9
https://originality-diplomiks24.com
https://originality-diplomiki24.com
https://ru-diplomirovan.com
https://ru-diplomirovany.com
www.ru-diplomirovanay.com
https://ru-diplomirovannie.com
rudiplomir.com
rudiplomirs.com
www.rudiplomira.com
rudiplomiry.com
https://rudiplomiru.com
ab-diplom24.ru
www.ab-diplom24.ru
http://www.24diplom07.ru
http://landik-attestats365.com
http://study-diploms.com}
9
11
9
http://diplomsagroups.com/kupit-diplom-o-srednem-obrazovanii/diplom-o-srednem-i-srednem-specialnom-obrazovanii.html
11
http://diplomsagroups.com/kupit-attestat-shkoly.html
https://premialnie-diplomansy.com/----/
https://premialnie-diplomansy.com/----/
https://premialnie-diplomansy.com/--/
https://russiany-diplomans.com/attestat-9-klassov
https://russiany-diplomans.com/srednee-spetsialnoe-obrazovanie
https://russiany-diplomans.com/kupit-diplom-kolledzha
https://russiany-diplomans.com/diplom-magistra
http://lands-diploms.com/ http://lands-diploms.com/specialnosti/yurist.html http://lands-diploms.com/goroda/krasnodar.html http://lands-diploms.com/goroda/omsk.html http://lands-diploms.com/goroda/chelyabinsk.html
http://aurus-diploms.com/attestat-9-klass.html http://aurus-diploms.com/obrazovanie/kupit-diplom-s-zaneseniem-v-reestr.html http://aurus-diploms.com/diplom-magistra.html http://aurus-diploms.com/geography/kupit-diplom-v-samare.html
http://radiploma.com/kupit-diplom-s-reestrom http://radiploma.com/kupit-diplomy-tehnikuma-kolledzha http://radiploma.com/kupit-diplomy-o-srednem-tehnicheskom-obrazovanii http://radiploma.com/kupit-diplom-kosmetologa
https://aurus-diplomans.com http://www.diplomas-asx.com https://diplomana-asx.com www.rusd-diplom.com https://rusd-diploms.com https://aurus-diplomany.com https://aurus-diplomik.com www.aurus-diplomas.com https://diplomans-asx.com diplomany-asx.com http://www.diplomys-asx.com https://diploman-servise.com http://www.radiploms.com http://www.radiplom.com radiplomy.com radiploma.com rudiplomisty24.com/--- http://www.rudiplomisty24.com/--- www.rudiplomisty24.com/--- rudiplomisty24.com/--
www.originality-diploman.com/----- originality-diploman.com/- originality-diploman.com/- www.originality-diploman.com/--
www.gosznac-diplomy.com/kupit-diplom-o-srednem-texnicheskom-obrazovanii www.gosznac-diplomy.com/diplom-spetcialista https://gosznac-diplomy.com/kupit-diplom-v-cheliabinske
diploman-asx.com/kupit-diplom-moskva https://diploman-asx.com/otzyvy http://www.diploman-asx.com/kupit-diplom-bakalavra-ili-specialista https://diploman-asx.com/kupit-diplom-specialista
11
http://www.diplom-belarus.com
diplomi-price.com
edu-digest.ru
http://proobzh.ru
http://www.edu-nt.ru/
http://www.student-madi.ru
http://dof-edu.ru
9
http://proobzh.ru
www.krsk-school47.ru http://www.russdiplomik.com/kupit-diplom-v-moskve.html russdiplomik.com/diplom-farmaczevta.html russdiplomik.com/diplom-s-reestrom-o-vyisshem-obrazovanii.html http://www.russdiplomik.com/kupit-diplom-v-novosibirske.html
http://www.russdiplomik.com/diplom-czena.html www.russdiplomik.com/diplom-farmaczevta.html russdiplomik.com/kupit-diplom-sankt-peterburg.html russdiplomik.com/kupit-diplom-v-ekaterinburge.html https://russiany-diplomans.com/diplom-o-srednem-obrazovanii http://www.russiany-diplomans.com/kupit-diplom-vracha www.russiany-diplomans.com/kupit-diplom-ekaterinburg http://www.russiany-diplomans.com/kupit-diplom-pskov https://arena-diplom24.com/attestaty https://arena-diplom24.com/diplomy-po-spetsialnosti/diplom-yurista https://ryazan.arena-diplom24.com/ http://www.novorossijsk.arena-diplom24.com/ www.diploms-goznak.com/attestat-vechernej-shkoly http://diploms-goznak.com/kupit-diplom-v-dnepropetrovske http://www.diploms-goznak.com/kupit-diplom-v-zhitomire http://diploms-goznak.com/kupit-diplom-v-zaporozhe - www.diploms-goznak.com/kupit-diplom-v-odesse diploms-goznak.com/vrach www.diploms-goznak.com/diplom-uchilishcha www.diploms-goznak.com/diplom-starogo-obraztsa http://www.diploms-goznak.com/diplom-tekhnikuma-kolledzha diploms-goznak.com/farmatsevt diploms-goznak.com/yurist http://diploms-goznak.com/meditsinskij-diplom diploms-goznak.com/svidetelstvo-o-rozhdenii
https://diplomy-servise.com
diploman-dok.com
diploman-doks.com
diploman-doky.com
www.diploman-doku.com http://education-ua.com/kupit-legalnyij-diplom-v-ukraine.html
www.education-ua.com/attestat-diplom.html
education-ua.com/zaporozhe.html
education-ua.com/kieve.html
http://education-ua.com/odesse.html
http://education-ua.com/summah.html
9
http://education-ua.com/ternopole.html
education-ua.com/diplom-o-mediczinskom-obrazovanii.html
http://www.education-ua.com/diplom-vyisshee.html
http://education-ua.com/kupit-nastoyashhij-diplom-goznak.html
http://www.education-ua.com/
education-ua.com/diplom-texnikuma-kolledzha.html
education-ua.com/diplom-magistra-ukrainskogo-vuza.html
http://www.education-ua.com/diplom-o-mediczinskom-obrazovanii.html
http://www.education-ua.com/diplom-medsestry.html
www.education-ua.com/diplom-nedorogo.html
http://education-ua.com/kupit-diplom-novogo-obrazca.html
www.education-ua.com/otzivi-pogelania.html
www.education-ua.com/diplom-vyisshee.html
http://education-ua.com/diplom-uchilishha.html
http://education-ua.com/diplom-s-registracziej.html
http://www.education-ua.com/kupit-diplom-s-provodkoj-v-ukraine.html
http://www.education-ua.com/diplom-specialista-ukrainskogo-vuza.html
http://www.education-ua.com/diplom-uchilishha.html
http://www.education-ua.com/kupit-diplom-sssr-na-nastoyashhem-blanke.html
http://education-ua.com/svidetelstvo-o-rozhdenii.html
11
http://education-ua.com/svidetelstvo-o-smerti.html
education-ua.com/svidetelstvo-o-brake.html
www.education-ua.com/svidetelstvo-o-razvode.html http://rudiplomisty24.com/-11- https://diplomy-servise.com http://dipplomy.com www.egpu.ru http://vina-net.ru/ cursovik.ru www.spravkipiter.ru alcoself.ru www.school625.ru www.moek-college.ru www.mmcmedclinic.ru www.intimvisit.ru http://med-pravo.ru/ http://moskva-medcentr.ru/ intim-72.ru razigrushki.ru www.dgartschool.ru www.ftbteam.ru http://sb26.ru/ http://www.originaly-dokuments.com/attestaty/attestat-za-9-klass https://originaly-dokuments.com/diplom-o-srednem-spetsialnom-obrazovanii https://originaly-dokuments.com/gorod/nizhnij-tagil https://originaly-dokuments.com/gorod/vologda www.originaly-dokuments.com/gorod/saratov https://originaly-dokuments.com/spetsialnosti/yurist originaly-dokuments.com/spetsialnosti/povar www.originaly-dokuments.com/gorod/krasnodar originaly-dokuments.com/attestaty/attestat-za-11-klass http://www.originaly-dokuments.com/gorod/ekaterinburg www.originaly-dokuments.com/attestaty https://originaly-dokuments.com/spetsialnosti/bukhgalter www.originaly-dokuments.com/gorod/omsk originaly-dokuments.com/gorod/novosibirsk www.originaly-dokuments.com/gorod/sankt-peterburg originaly-dokuments.com/gorod/chelyabinsk www.originaly-dokuments.com/gorod/orjol originaly-dokuments.com/diplom-o-vysshem-obrazovanii/diplom-bakalavra originaly-dokuments.com/diplom-o-vysshem-obrazovanii/diplom-magistra www.originaly-dokuments.com/spetsialnosti/menedzher https://originaly-dokuments.com/diplom-o-srednem-spetsialnom-obrazovanii/diplom-kolledzha https://originaly-dokuments.com/diplom-o-srednem-spetsialnom-obrazovanii
- - - -- - - premialnie-diplomansy.com https://premialnie-diplomansy.com/--/ www.premialnie-diplomansy.com www.originality-diploman.com originality-diploman.com https://originality-diploman.com/-- originality-diploman.com https://originality-diploman.com/-- https://originality-diploman.com/---- www.originality-diploman.com http://https://originality-diploman.com/-- premialnie-diplomansy.com originality-diploman.com www.premialnie-diplomansy.com premialnie-diplomansy.com https://premialnie-diplomansy.com/--/ https://premialnie-diplomansy.com/--/ www.premialnie-diplomansy.com www.premialnie-diplomansy.com http://https://originality-diploman.com/--
9
www.gosznac-diplomy.com http://https://gosznac-diplomy.com/kupit-diplom-vuza-rossii http://https://gosznac-diplomy.com/diplom-sredne-spetcialnoe-obrazovanie http://https://gosznac-diplomy.com/kupit-diplom-v-moskve gosznac-diplomy.com gosznac-diplomy.com https://gosznac-diplomy.com/svidetelstvo-o-rozhdenii http://https://gosznac-diplomy.com/diplom-feldshera gosznac-diplomy.com https://gosznac-diplomy.com/diplom-stroitelya
9 9 11
originality-diplomans.com
rudiplomis24.com
www.diploma-asx.com
https://gosznac-diplom.com/ diploman-doci.com
https://originality-diplomans.com/
www.rudiplomis24.com
https://lands-diplom.com/
https://gosznac-diplom.com/ http://https://aurus-diplom.com/
https://originality-diplomans.com/
https://rudiplomista24.com/
www.diploma-asx.com
https://gosznac-diplom.com/ https://aurus-diplom.com/
http://https://originality-diplomans.com/
https://rudiplomista24.com/
https://lands-diplom.com/
www.gosznac-diplom.com http://https://aurus-diplom.com/
http://diplomsagroups.com/diplomy-po-specialnosti/diplom-buhgaltera.html www.originality-diploman24.com https://originality-diplomans.com/ https://originality-diploma24.com/- http://https://frees-diploma.com https://ekaterinburg.arena-diplomi24.com/ http://https://ekaterinburg.arena-diplomi24.com/