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No Expression of Human Leukocyte Antigen G (HLA-G) in Colorectal Cancer Cells

816

Kawin Leelawat MD, PhD*,**, Surang Engprasert PhD***,
Urai Pongchai-rerk DVM*, Supatip Tuchinda MSc****,
Cheepsumon Suthipintawong MD****, Vijittra Leardkamolkarn PhD*
* Department of Anatomy, Faculty of Science, Mahidol University
** Department of Surgery, Rajavithi Hospital
*** Department of Pharmacognosy, Faculty of Pharmaceutical Science, Kyushu University, Japan
**** Department of Pathology, Rajavithi Hospital

Abstract


Although there is a specific antitumor immune response in the body, colorectal cancer cells progressively develop. This fact indicated that the cancer cells could have a variety of mechanisms to evade or escape the immune system. HLA-G is identified to inhibit the recognition of NK-cell in various kinds of cancers. This study investigated the expression of HLA-G in colorectal cancer. Eighty five specimens of colorectal cancer, carcinoma in situ and adenomatous polyp were examined by immunohistochemistry and RT-PCR for the detection of human leukocyte antigen (HLA)-G. The expression of HLA-G was not found in all colorectal specimens (85/85) both protein level and transcription level, suggesting that the expression of HLA-G is not a possible immune evasion mechanism of colorectal cancer cell.

Keyword : Immune evasion, Colorectal cancer, Adenomatous polyp, HLA-G



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