Proundly Supported by
Pfizer Foundation
    Home | Current Issue | Past Issue | Board | Instruction | Contact

No Expression of Human Leukocyte Antigen G (HLA-G) in Colorectal Cancer Cells


Kawin Leelawat MD, PhD*,**, Surang Engprasert PhD***,
Urai Pongchai-rerk DVM*, Supatip Tuchinda MSc****,
Cheepsumon Suthipintawong MD****, Vijittra Leardkamolkarn PhD*
* Department of Anatomy, Faculty of Science, Mahidol University
** Department of Surgery, Rajavithi Hospital
*** Department of Pharmacognosy, Faculty of Pharmaceutical Science, Kyushu University, Japan
**** Department of Pathology, Rajavithi Hospital


Although there is a specific antitumor immune response in the body, colorectal cancer cells progressively develop. This fact indicated that the cancer cells could have a variety of mechanisms to evade or escape the immune system. HLA-G is identified to inhibit the recognition of NK-cell in various kinds of cancers. This study investigated the expression of HLA-G in colorectal cancer. Eighty five specimens of colorectal cancer, carcinoma in situ and adenomatous polyp were examined by immunohistochemistry and RT-PCR for the detection of human leukocyte antigen (HLA)-G. The expression of HLA-G was not found in all colorectal specimens (85/85) both protein level and transcription level, suggesting that the expression of HLA-G is not a possible immune evasion mechanism of colorectal cancer cell.

Keyword : Immune evasion, Colorectal cancer, Adenomatous polyp, HLA-G

Download Full Paper
  Vol87_No7_816.pdf  [ 201.57 Kb]

Home | Current Issue | Past Issue | Board | Instruction | Contact

© Copyright The Medical Association of Thailand. All Rights Reserved.2001-2002
Acquista Cialis generico 5 mg Effetti collaterali del Cialis 5 mg Acquista Cialis 20mg online Prezzo di Cialis originale in Svizzera Acquista Viagra in Svizzera senza prescrizione Dove comprare Cialis 10mg Viagra in farmacia online effetti collaterali Costo di Cialis 5mg Opiniones de Reduslim Acquista Spedra Avanafil senza prescrizione Acquista Viagra in Svizzera senza prescrizione Comprar Cialis original Comprar Viagra Contrareembolso Cialis 5mg Viagra sin receta Cialis 5 mg efectos secundarios graves Reduslim precio Trastorno de la ereccin venta de tadalafilo avanafil prezzo cialis 20 mg prezzo cialis effetti benefici cialis 10 mg Reduslim Kaufen pulse crypto price prediction avanafil 100 mg prezzo