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Efficacy of Benzimidazole Carbamate on an Intestinal Fluke Co-Infected with Nematodes


Jitra Waikagul, PhD*, Dorn Watthanakulpanich, MSc*,
Chatree Muennoo, BEd*, Wanna Maipanich, MSPH*,
Surapol Sa-nguankiat, BEd*, Somchit Phubampen, BBA*

* Department of Helminthology, Faculty of Tropical Medicine, Mahidol University


The efficacy of a single dose of benzimidazole, drugs commonly used for the treatment of Ascaris and hookworm, was evaluated against one of the tiny-sized intestinal flukes, Haplorchis sp in the endemic area where mixed infections of roundworms and flatworms existed. At day 7 after treatment, albendazole (400 mg) induced 42.5% cure rate, mebendazole (500 mg) a cure rate of 32.4%, on the other hand, praziquantel (40mg/kg) gave 94.6% cure rate and the placebo at 15.9%. At the single dose, benzimidazole could not completely expelled the haplorchid; but could reduce one third to two fifth of the infection, similar to the drugs efficacy against Trichuris infection.

Keyword : Haplorchis sp, Treatment, Single dose, Albendazole, Mebendazole

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